Does gemcitabine cause thrombocytopenia?
Does gemcitabine cause thrombocytopenia?
Gemcitabine-based combinations are associated with more thrombocytopenia than single-agent gemcitabine (40 versus 7%). However, clinical complications such as grades 3 and 4 hemorrhage are uncommon. A 21-day schedule is associated with less thrombocytopenia than a 28-day schedule.
Can chemotherapy cause thrombocytopenia?
Chemotherapy-induced thrombocytopenia (CIT) is a potentially serious complication that can lead to chemotherapy dose delays, dose reductions, or discontinuation, and increases the risk of serious bleeding events.
What causes low platelets in cancer patients?
In patients with cancer, low platelet count may be caused by: Certain types of cancer: patients with lymphomas or leukemias may be at higher risk for low platelet counts. Certain types or cancer treatment, such as chemotherapy or radiation therapy that is used in large amounts or in combination with chemotherapy.
How do chemo patients increase platelets?
Is there a natural way to increase platelet levels?
- Folate (vitamin B9)-rich foods such as green leafy vegetables, beans, peanuts, liver, and seafood.
- Foods rich in vitamins B-12, C, D, and K, such as beef, liver, chicken, fish, seafood, citrus, tomatoes, potatoes, egg yolks, and cereals.
What are the mechanisms involved in chemotherapy induced thrombocytopenia?
Each chemotherapy agent differs in how it causes thrombocytopenia: alkylating agents affect stem cells, cyclophosphamide affects later megakaryocyte progenitors, bortezomib prevents platelet release from megakaryocytes, and some treatments promote platelet apoptosis.
Which chemotherapy drugs cause low platelets?
The chemotherapy regimens most likely to result in thrombocytopenia were dexamethasone, cytarabine, cisplatin (DHAP) (92.3%), isophosphamide, carboplatin, etoposide (ICE) (89.7%), gemcitabine, dexamethasone, cisplatin (GDP) (89.7%), gemcitabine, and oxaliplatin (Gemox) (69.0%).
How do chemo patients keep their platelets up?
Having low platelets (the medical term is thrombocytopenia) during chemotherapy is reasonably common and the most common way to increase platelet count during chemotherapy is to either delay the next dose of chemotherapy or to have a platelet transfusion administered by your healthcare provider.
What happens if platelets are low in cancer patients?
Low numbers of platelets in your blood can cause bleeding. You might bleed excessively from a small cut or bleed spontaneously from your nose or gums. Rarely, dangerous internal bleeding can occur. A low platelet count can delay your treatment.
