What is irradiation of RBC?

Irradiation of red blood cells and whole blood results in reduced post transfusion red cell recovery and increases the rate of efflux of intracellular potassium. It has no clinically significant effect on red cell pH, glucose, 2,3 DPG levels or ATP.

Why do we irradiate blood products?

Irradiating blood components prevents the donor white cells replicating and mounting an immune response against a vulnerable patient causing transfusion-associated-graft-versus-host disease (TA-GvHD). Who should you inform if your patient requires irradiated blood components?

Who requires irradiated blood?

People who have had CAR T-cell therapy should have irradiated blood products for at least 3 months after their treatment. People who’ve been treated with certain chemotherapy drugs, including fludarabine, cladribine, bendamustine and pentostatin, should have irradiated blood products for the rest of their lives.

What happens to irradiated blood?

Does irradiation damage the blood? Irradiation does not cause any significant damage. The blood does not become ‘radioactive’ and will not harm you or anyone around you.

When do you irradiate RBC?

Guidelines are in place to optimize RBC quality while ensuring maximum white blood cells damage. The Canadian guidelines state that RBC units can be stored in a refrigerator for up to 42 days before transfusion, and that irradiation of the unit can take place at any time during this storage period.

Why are red cells irradiated?

As described in the Technical Manual (20th Edition) and Circular of Information (October 2017), cellular blood components are irradiated prior to transfusion to prevent the proliferation of viable T lymphocytes which are the immediate cause of Transfusion Associated-Graft Versus Host Disease (TA-GVHD).

When do you give blood irradiated?

To prevent ta-GvHD, irradiated blood products should be given to patients at risk: patients after bone marrow transplantation, newborns and children in the 1st year, patients with severe combined immunodeficiency, and patients receiving blood from first-degree relatives.

When should you irradiate blood?

What does it mean to irradiate the cells?

Listen to pronunciation. (ih-RAY-dee-AY-shun) The use of high-energy radiation from x-rays, gamma rays, neutrons, protons, and other sources to kill cancer cells and shrink tumors.

What is irradiation of cells?