What is tolerogenic dendritic cell?

Tolerogenic dendritic cells (a. k. a. tol-DCs, tDCs, or DCregs) are heterogenous pool of dendritic cells with immuno-suppressive properties, priming immune system into tolerogenic state against various antigens.

What is a tolerogenic response?

Tolerogenic therapy aims to induce immune tolerance where there is pathological or undesirable activation of the normal immune response.

What are tDC cells?

Tolerogenic dendritic cells (tDCs) represent a promising tool for cellular therapy against autoimmune diseases, allergies, and transplantation rejection. Numerous pharmacological agents are known to induce tDC generation.

Why is the liver tolerogenic?

The liver is a tolerogenic organ with exquisite mechanisms of immune regulation that ensure upkeep of local and systemic immune tolerance to self and foreign antigens, but that is also able to mount effective immune responses against pathogens.

What is Tolergen?

A foreign antigen that suppresses immune response, or produces immune tolerance. Supplement.

Why is the liver Immunotolerant?

Liver immunology is very specific, and liver immunotolerance is particularly developed because of the constant and massive influx of antigens. Deregulation of hepatic immunotolerance is implicated in chronic liver diseases development and particularly in liver carcinogenesis.

How are Neoantigens made?

Neoantigens are mainly tumor-specific antigens generated by mutations in tumor cells, which are only expressed in tumor cells (11). Neoantigens can also be produced by viral infection, alternative splicing and gene rearrangement (12–14).

What are the two types of immunological tolerance?

Immunologic tolerance occurs in two forms: central and peripheral.

Where is interleukin-2 produced?

Abstract. Interleukin 2 (IL-2) is a monomeric glycoprotein that is primarily produced by activated CD4+ T cells, CD8+ T cells and dendritic cells. It is characterized as a proinflammatory cytokine that is secreted by Th1 cells.

What is the mechanism of action of interleukin-2?

Abstract. The T cell lymphokine, interleukin-2 (IL-2), plays a pivotal role in an immune response by stimulating antigen-activated B lymphocytes to progress through the cell cycle and to differentiate into antibody-secreting cells.