What is Mullerian adenocarcinoma?

A rare cancer of the uterus, ovary, or fallopian tubes.

What is adenocarcinoma of Mullerian origin?

Adenocarcinoma of Mullerian origin, previously, known as ‘mesothelioma of pelvic origin’, is a rare primary malignancy of the peritoneum [1]. It is frequently found identical to papillary serous adenocarcinoma of the ovary, hence, also referred to as extraovarian peritoneal serous papillary carcinoma.

Is adenocarcinoma an epithelial cancer?

Adenocarcinomas. Adenocarcinoma is a family of cancers that start in specialized epithelial cells, called glandular cells. Glandular cells are found in the linings of most organs and secrete a substance like mucus.

What is high-grade Mullerian adenocarcinoma?

High-grade Mullerian cancers display predominantly serous histology, but also include some endometrial carcinomas, carcinosarcomas, and undifferentiated cancers.

What is Mullerian epithelium?

Definition. All epithelia of the female genital tract derived from the embryonal Müllerian ducts. Includes the epithelia of the fallopian tubes, endometrium, endocervix, ectocervix, and upper vagina.

What is the meaning of Mullerian?

: of, relating to, or being mimicry that exists between two or more inedible or dangerous species (as of butterflies or bees) and that is considered in evolutionary theory to be a mechanism which reduces loss to predation by simplifying the warning colors and patterns a predator must recognize Mullerian mimicry differs …

Is high-grade serous carcinoma curable?

Is high-grade serous ovarian carcinoma curable? Patients with HGSOC often respond well to treatment, and can experience remission — however, it is common for high-grade serous patients to recur over a period of time, with the majority of recurrences occurring within three years.

What is the survival rate for high grade serous carcinoma?

Outcomes for patients with this type of ovarian cancer vary on an individual basis; currently, the median overall survival for patients with high-grade serous ovarian carcinoma is about 40 months.

How long can you live with serous carcinoma?

Background: Advanced-stage (III/IV) uterine papillary serous carcinoma (UPSC) has a median overall survival (OS) of ~ 3 yrs.

What is the Müllerian?

The müllerian ducts are the primordial anlage of the female reproductive tract. They differentiate to form the fallopian tubes, uterus, the uterine cervix, and the superior aspect of the vagina. A wide variety of malformations can occur when this system is disrupted.

What is a Müllerian defect?

During typical fetal development, two tube-like structures called the Müllerian ducts fuse together to create the uterus, fallopian tubes and majority of the vagina. When one of these structures does not fully develop, a malformation of the uterus or vagina occurs, and this is referred to as a Müllerian anomaly.

What does serous adenocarcinoma mean?

Abstract. Uterine serous adenocarcinoma (USC) is rare and invasive cancer. This cancer is more often reported in the ovary, the fallopian tube, and the endometrium than uterine cervix. No matter where the tumor is located, the tumor exhibits similar histological characteristics.

What causes serous adenocarcinoma?

Specific risk factors for uterine serous carcinoma include a personal history of breast cancer, tamoxifen exposure, and hereditary cancer syndromes. Common clinical features include older age and higher stage at diagnosis, and mutations in p53.

What is peritoneal adenocarcinoma of Mullerian Type?

Peritoneal adenocarcinoma (serous) of Mullerian type: a subgroup of women presenting with peritoneal carcinomatosis. Int J Gynecol Cancer.

What are the molecular determinants of adenocarcinoma of Mullerian origin?

Molecular determinants of adenocarcinoma of Mullerian origin The data regarding the molecular determinants of adenocarcinoma of Mullerian origin is primarily based on genomic studies of EOC [92]. However, some studies do include tubal and peritoneal cancers.

What is the relationship between the Mullerian epithelium and the peritoneum?

Therefore, while the reproductive organs and peritoneum originate from distinct pathways, the Mullerian epithelia, OSE, and peritoneal (coelomic) epithelium have a close developmental relationship (Figure 1) [25]. Open in a separate window Figure 1 Transverse section through the urogenital ridge.

Which histologic findings are characteristic of Mullerian cancer?

High-grade serous ovarian, tubal, and peritoneal carcinoma High-grade Mullerian cancers display predominantly serous histology, but also include some endometrial carcinomas, carcinosarcomas, and undifferentiated cancers.