What happens if there is too much E2F?
What happens if there is too much E2F?
Cells with elevated E2F transcription fail to exit the cell cycle after DNA damage, which potentially causes genomic instability, promotes malignant progression, and reduces drug sensitivity.
How does p53 lead to senescence?
The p53 transcription factor plays a critical role in cellular responses to stress. Its activation in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs cellular senescence or apoptosis, thereby maintaining genome integrity.
What is E2F in cell cycle?
E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six others act as suppressors: E2F3b, E2F4-8. All of them are involved in the cell cycle regulation and synthesis of DNA in mammalian cells.
Is E2F a tumor suppressor gene?
Although it can function as an oncogene, E2F-1 has also been postulated to be a tumor suppressor because it can induce apoptosis. Mice with a homozygous deletion of E2F-1 have a defect in thymocyte apoptosis, show increased cellular proliferation, and eventually develop numerous tumors [43,201].
What is E2F protein?
E2F is a cellular transcription factor that is necessary for the transactivation of the adenoviral E2 promoter and thus the expression of viral DNA replication proteins.
What is Rb and E2F?
The RB/E2F pathway regulates apoptosis, and RB inhibition of apoptosis is an important mechanism of tumor suppression whereby cells deficient for RB function can be eliminated by apoptosis. One manner through which RB can inhibit apoptosis is through its binding to RNA processing factors.
Is E2F a tumor suppressor or oncogene?
What happens when E2F is mutated?
Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol Cell.
Is Rb a tumor suppressor gene or oncogene?
Abstract. The Rb protein is a tumor suppressor, which plays a pivotal role in the negative control of the cell cycle and in tumor progression. It has been shown that Rb protein (pRb) is responsible for a major G1 checkpoint, blocking S-phase entry and cell growth.
