Is octreotide a somatostatin analog?

The most common somatostatin analogue drugs used are octreotide (also known as Sandostatin) and lanreotide (also known as Somatuline Autogel).

What is the difference between octreotide and somatostatin?

Somatostatin is an orphan drug manufactured by Ferring Laboratories of Tarrytown, NY, under the trade name Reducin. Octreotide (Sandostatin) is a long-acting synthetic analogue of somatostatin. It has similar qualitative effects, but differs in potency and selectivity for target issues.

Does octreotide inhibit somatostatin?

Conclusions. Octreotide is a potent synthetic somatostatin analogue that has become the mainstay of medical therapy for tumor control in neuroendocrine disorders such as acromegaly and GEP-NETs.

What receptor does octreotide bind to?

The somatostatin analogue, octreotide, binds with high affinity to the SSTR2 and SSTR5 subtype and with a low affinity to the SSTR3 subtype. This analogue does not bind to the SSTR1 and SSTR4 subtypes.

What hormones does octreotide inhibit?

Octreotide’s suppression of luteinizing hormone (LH) 3, reduction in splanchnic blood flow 4, and inhibition of serotonin, gastrin, vasoactive intestinal peptide, secretin, motilin, and pancreatic polypeptide provide relief for the gastrointestinal and flushing symptoms of carcinoid and/or VIPoma tumors.

What do somatostatin receptors do?

The somatostatin family of receptors consists of five subtypes, differentially distributed throughout the CNS and periphery. Activation of these receptors stimulates multiple intracellular cascades to modulate growth hormone release, insulin and glucagon secretion, gastric acid secretion and neuronal activity.

Is octreotide a somatostatin agonist?

Somatostatin receptor agonists Octreotide andlanreotide are synthetic analogues of somatostatin, which act selectively on somatostatin receptor subtypes (SSTR2 and SSTR5) and are highly expressed in GH-secreting tumours.

What kind of drug is octreotide?

Drug type: Octreotide is hormone drug that is used to treat some types of cancer. This medication is classified as a somatostatin analog.